[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Li X.M., Liu J., Pan F.F., Shi D.D., Wen Z.G., Yang P.L
Safety Profile, Side Effects, and Contraindications MOTS-c has a favorable safety profile in the published research to date, which is unsurprising given that it is an endogenous peptide that naturally circulates in human blood
For users experiencing the common GI side effects of triple agonist therapy, this support can make the difference between tolerating treatment and discontinuing

Food additives Maltodextrin, dextrose, glucose syrup Artificial sweeteners, which may support fungal growth or disrupt gut balance Emulsifiers (e.g., polysorbate 80) or stabilizers may negatively affect gut barrier integrity Foods and strategies that help suppress candida While eliminating or reducing the above, you can focus on foods that support gut resilience and microbial balance: Non-starchy, fibrous vegetables: Leafy greens, broccoli, cauliflower, asparagus, Brussels sprouts, zucchini, cucumbers Low-glycemic fruits (in moderation): Berries (blueberry, strawberry, raspberry), green apples, and small portions of citrus Lean proteins: Eggs, fish, poultry, tofu, tempeh (if tolerated) Healthy fats: Olive oil, avocado, coconut (in moderation), nuts/seeds (if tolerated) Fermented foods / probiotic foods (carefully introduced): Unsweetened sauerkraut, kimchi, kefir or yogurt (if tolerated), coconut yogurt (sugar-free)